Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment
Binzhou Medical University · State Administration of Traditional Chinese Medicine of the People's Republic of China · +1 more institution
Abstract
The metabolic activity of tumor cells leads to the acidification of the surrounding microenvironment, which provides new strategies for the application of nanotechnology in cancer therapy. Researchers have developed various types of pH-responsive nanomaterials based on the tumor acidic microenvironment. This review provides an in-depth discussion on the design mechanisms, drug-loading strategies, and application pathways of tumor acidic microenvironment-responsive nanodrug delivery systems. These materials trigger drug release upon reaching the tumor microenvironment, enhancing therapeutic targeting and reducing toxicity to healthy cells. pH-responsive nanomaterials include organic nanomaterials, inorganic…
Citation impact
- FWCI
- 41.84
- Percentile
- 100%
- References
- 109
Authors
8- YLYunheng LiuCorresponding
Binzhou Medical University, State Administration of Traditional Chinese Medicine of the People's Republic of China
- LSLei Si
Binzhou Medical University, State Administration of Traditional Chinese Medicine of the People's Republic of China
- YJYuxuan Jiang
Binzhou Medical University, State Administration of Traditional Chinese Medicine of the People's Republic of China
- SJShaojing Jiang
Binzhou Medical University, Binzhou University
- XZXiaokang Zhang
Binzhou Medical University, State Administration of Traditional Chinese Medicine of the People's Republic of China
Topics & keywords
- Nanomaterials
- Tumor microenvironment
- Drug delivery
- Nanotechnology
- Cancer therapy
- Materials science
- Chemistry
- Cancer