Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and the subsequent release of mitochondrial DNA (mtDNA), which is anticipated to activate the cGAS-STING pathway, thereby augmenting the antitumor immune response. However, challenges lie in effectively triggering pyroptosis in cancer cells and subsequently enhancing the cGAS-STING activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators of cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 nanocatalysts with a semiconductor structure and enzyme-like activity generated a substantial amount of reactive oxygen species (ROS) under stimulation by endogenous…

• NN
  National Natural Science Foundation of China

  Awards: 52072253, 52403386, U20A20254, 52472288
• FP
  Fundo para o Desenvolvimento das Ciências e da Tecnologia

  Awards: 0118/2023/RIA2, 0064/2024/AMJ, 0016/2024/RIA1
• CI
  Collaborative Innovation Center of Suzhou Nano Science and Technology
• HE
  Higher Education Discipline Innovation Project
• JP
  Jiangsu Planned Projects for Postdoctoral Research Funds
• NK
  National Key Research and Development Program of China

  Award: 2022YFB3804600
• NS
  Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars

  Award: BK20211544