An injectable multi-functional composite bioactive hydrogel for bone regeneration via immunoregulatory and osteogenesis effects
Fudan University · Huashan Hospital · +12 more institutions
Abstract
Bone defects represent a prevalent and significant challenge in clinical practice. Given the inflammatory microenvironment at injury sites and the requirement for endogenous cell and tissue infiltration, there is an urgent need for an ideal biomaterial that can modulate inflammation and promote bone regeneration. We developed an innovative injectable hydrogel (CH@PUE&MSN) designed for immunomodulation and bone regeneration through in situ self-assembly, incorporating puerarin and chitosan with mesoporous silica nanoparticles. In vitro experiments demonstrated that this multifunctional injectable hydrogel promotes tissue cell regeneration, reduces inflammation, inhibits osteoclast formation, induces the…
Citation impact
- FWCI
- 24.82
- Percentile
- 100%
- References
- 54
Authors
16- YHYanwei He
Fudan University, Huashan Hospital
- ZLZhiwen Luo
Fudan University, Huashan Hospital
- XNXiaoshuang Nie
Chinese Academy of Sciences, Shanghai Institute of Ceramics, University of Chinese Academy of Sciences
- DYDU Yi-min
Affiliated Hospital of Southwest Medical University
- RSRong SunCorresponding
Nanjing General Hospital of Nanjing Military Command, Nanjing University
Topics & keywords
- Regeneration (biology)
- Composite number
- Bone healing
- Biomedical engineering
- Dentistry
- Chemistry
- Medicine
- Materials science