Patient‐derived xenograft model in cancer: establishment and applications
Shanghai Jiao Tong University · Renji Hospital · +2 more institutions
Abstract
The patient-derived xenograft (PDX) model is a crucial in vivo model extensively employed in cancer research that has been shown to maintain the genomic characteristics and pathological structure of patients across various subtypes, metastatic, and diverse treatment histories. Various treatment strategies utilized in PDX models can offer valuable insights into the mechanisms of tumor progression, drug resistance, and the development of novel therapies. This review provides a comprehensive overview of the establishment and applications of PDX models. We present an overview of the history and current status of PDX models, elucidate the diverse construction methodologies employed for different tumors, and conduct…
Citation impact
- FWCI
- 43.78
- Percentile
- 100%
- References
- 209
Authors
4- AGAo Gu
Shanghai Jiao Tong University, Renji Hospital, Zero to Three
- JLJiatong Li
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute, Zero to Three
- MLMengyao LiCorresponding
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute
- YLYingbin LiuCorresponding
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute
Topics & keywords
- Cancer
- Personalized medicine
- Precision medicine
- Radiation therapy
- Medicine
- Cancer therapy
- Cancer treatment
- Computational biology
- Good health and well-being