Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration

Reconstructing large, inflammatory maxillofacial defects using stem cell-based therapy faces challenges from adverse microenvironments, including high levels of reactive oxygen species (ROS), inadequate oxygen, and intensive inflammation. Here, inspired by the reaction mechanisms of intracellular antioxidant defense systems, we propose the de novo design of an artificial antioxidase using Ru-doped layered double hydroxide (Ru-hydroxide) for efficient redox homeostasis and maxillofacial bone regeneration. Our studies demonstrate that Ru-hydroxide consists hydroxyls-synergistic monoatomic Ru centers, which efficiently react with oxygen species and collaborate with hydroxyls for rapid proton and electron…

• SU
  Sichuan University

  Award: ZYJC21047
• SK
  State Key Laboratory of Polymer Materials Engineering

  Award: sklpme2021-4-02
• NK
  National Key Research and Development Program of China

  Awards: 2023YFC3605600, 2024YFE0201200, 202206
• WC
  West China Hospital, Sichuan University

  Award: ZYJC21047