reviewNature CommunicationsJan 21, 2025GOLD OA

Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies

JDJesper Damsgaard GunstJGJesal GohilJZJonathan Z. LiRJRonald J. BoschCWCaitlin White

Aarhus University · Aarhus University Hospital · +29 more institutions

PubMed
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Abstract

The only current strategy to test efficacy of novel interventions for sustained HIV control without antiretroviral therapy (ART) among people with HIV (PWH) is through an analytical treatment interruption (ATI). Inclusion of ‘placebo’ controls in ATIs poses ethical, logistical, and economic challenges. To understand viral dynamics and rates of post-treatment control (PTC) after ATI among PWH receiving either placebo or no intervention, we undertook an individual-participant data meta-analysis. In total, 24 eligible prospective studies with 382 individuals with ≥5 plasma HIV RNA viral loads (pVLs) within the first 84 days post-ATI were included. Early-ART was defined as ART initiation within 6 months of HIV…

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Topics & keywords

Topics
Keywords
  • Interquartile range
  • Medicine
  • Viral load
  • Antiretroviral therapy
  • Psychological intervention
  • Placebo
  • Human immunodeficiency virus (HIV)
  • Prospective cohort study
UN Sustainable Development Goals
  • Good health and well-being
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