articleACS NanoJan 21, 2025Closed access

Prussian Blue Nanozyme Featuring Enhanced Superoxide Dismutase-like Activity for Myocardial Ischemia Reperfusion Injury Treatment

Advanced Materials and Devices (United States) · Southeast University · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The blood flow, when restored clinically following a myocardial infarction (MI), disrupts the physiological and metabolic equilibrium of the ischemic myocardial area, resulting in secondary damage termed myocardial ischemia-reperfusion injury (MIRI). Reactive oxygen species (ROS) generation and inflammatory reactions stand as primary culprits behind MIRI. Current strategies focusing on ROS-scavenging and anti-inflammatory actions have limited remission of MIRI. Prussian blue nanozyme (PBNz) exhibits multiple enzyme-like activities including catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD), which are beneficial for ROS clearance and fighting inflammation. Herein, a formulation of PBNz coated…

No related works found for this paper.

Funding