MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays
The University of Melbourne · Walter and Eliza Hall Institute of Medical Research · +13 more institutions
Abstract
Multiplexed assays of variant effect (MAVEs) are a critical tool for researchers and clinicians to understand genetic variants. Here we describe the 2024 update to MaveDB ( https://www.mavedb.org/ ) with four key improvements to the MAVE community's database of record: more available data including over 7 million variant effect measurements, an improved data model supporting assays such as saturation genome editing, new built-in exploration and visualization tools, and powerful APIs for data federation and streamlined submission and access. Together these changes support MaveDB's role as a hub for the analysis and dissemination of MAVEs now and into the future.
Citation impact
- FWCI
- 87.98
- Percentile
- 100%
- References
- 51
Authors
28- AFAlan F. RubinCorresponding
The University of Melbourne, Walter and Eliza Hall Institute of Medical Research
- JSJeremy Stone
Brotman Baty Institute
- AHAisha Haley Bianchi
University of Washington, Seattle University
- BJBenjamin J. Capodanno
Brotman Baty Institute
- EYEstelle Y. Da
Walter and Eliza Hall Institute of Medical Research
Topics & keywords
- Biology
- Visualization
- Computational biology
- Key (lock)
- Data science
- Genome
- Human genetics
- Database