Radical Brook rearrangement: past, present, and future

The Brook rearrangement has emerged as one of the most pivotal transformations in organic chemistry, with broad applications spanning organic synthesis, drug design, and materials science. Since its discovery in the 1950s, the anion-mediated Brook rearrangement has been extensively studied, laying the groundwork for the development of numerous innovative reactions. In contrast, the radical Brook rearrangement has garnered comparatively less attention, primarily due to the challenges associated with the controlled generation of alkoxyl radicals under mild conditions. However, recent advancements in visible-light catalysis and transition-metal catalysis have positioned the radical Brook rearrangement as a…

• NN
  National Natural Science Foundation of China

  Awards: 22471201, 22401222
• CP
  China Postdoctoral Science Foundation

  Awards: 2023TQ0250, 2024M752460
• NK
  National Key Research and Development Program of China

  Award: 2022YFA1506100