Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics
Beijing Biocytogen (China) · University of Science and Technology Beijing · +3 more institutions
Abstract
Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these therapeutics face numerous challenges in practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations in delivering them specifically to target tissues. To overcome these obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer nanoparticles, inorganic nanoparticles, protein carriers, exosomes, antibody oligonucleotide conjugates, and DNA nanostructure-based delivery systems. These systems enhance the therapeutic efficacy of nucleic…
Citation impact
- FWCI
- 36.57
- Percentile
- 100%
- References
- 269
Authors
8- XBXiaochun Bian
Beijing Biocytogen (China), University of Science and Technology Beijing
- LZLiping ZhouCorresponding
Beijing Biocytogen (China), University of Science and Technology Beijing
- ZLZhiwei Luo
Beijing Biocytogen (China), University of Science and Technology Beijing
- GLGuotao Liu
Beijing Biocytogen (China), University of Science and Technology Beijing
- ZHZhongci Hang
Beijing Biocytogen (China), University of Science and Technology Beijing
Topics & keywords
- Nucleic acid
- Nanotechnology
- Chemistry
- Computational biology
- Materials science
- Computer science
- Biology
- Biochemistry