Catalytic Asymmetric Dehydrogenative Si–H/X–H Coupling toward Si-Stereogenic Silanes

ConspectusChiral organosilicon compounds bearing a Si-stereogenic center have attracted increasing attention in various scientific communities and appear to be a topic of high current relevance in modern organic chemistry, given their versatile utility as chiral building blocks, chiral reagents, chiral auxiliaries, and chiral catalysts. Historically, access to these non-natural Si-stereogenic silanes mainly relies on resolution, whereas their asymmetric synthetic methods dramatically lagged compared to their carbon counterparts. Over the past two decades, transition-metal-catalyzed desymmetrization of prochiral organosilanes has emerged as an effective tool for the synthesis of enantioenriched Si-stereogenic…

• NN
  National Natural Science Foundation of China

  Awards: 22101113, 22271134, 22101120, 22122102
• ST
  Science, Technology and Innovation Commission of Shenzhen Municipality

  Awards: RCJC20221008092723013, JCYJ20230807093104009
• GP
  Guangdong Provincial Key Laboratory Of Catalysis

  Award: 2020B121201002
• GP
  Guangdong Provincial Pearl River Talents Program

  Award: 2019QN01Y628