AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
Universidad de Málaga · Instituto de Salud Carlos III
Abstract
Tetrameric AMPA-type ionotropic glutamate receptors are primary transducers of fast excitatory synaptic transmission in the central nervous system, and their properties and abundance at the synaptic surface are crucial determinants of synaptic efficacy in neuronal communication across the brain. The induction of long-term potentiation (LTP) leads to the insertion of GluA1-containing AMPA receptors at the synaptic surface, whereas during long-term depression (LTD), these receptors are internalized into the cytoplasm of the spine. Disruptions in the trafficking of AMPA receptors to and from the synaptic surface attenuate both forms of synaptic plasticity. Homeostatic scaling up and scaling down, which are…
Citation impact
- FWCI
- 34.36
- Percentile
- 100%
- References
- 189
Authors
3Topics & keywords
- AMPA receptor
- Synaptic plasticity
- Metaplasticity
- Synaptic scaling
- Long-term depression
- Neuroscience
- Ion channel linked receptors
- Synaptic fatigue