Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease

In Alzheimer's disease (AD), amyloid-β (Aβ) triggers the aggregation and spreading of tau pathology, which drives neurodegeneration and cognitive decline. However, the pathophysiological link between Aβ and tau remains unclear, which hinders therapeutic efforts to attenuate Aβ-related tau accumulation. Aβ has been found to trigger neuronal hyperactivity and hyperconnectivity, and preclinical research has shown that tau spreads across connected neurons in an activity-dependent manner. Here, we hypothesized that neuronal hyperactivity and hypersynchronicity, resulting in functional connectivity increases, constitute a crucial mechanism by which Aβ facilitates the spreading of tau pathology. By combining Aβ…

• UO
  University of Pennsylvania
• EU
  Emory University
• UO
  University of Pittsburgh
• BS
  Berlin-Brandenburg School for Regenerative Therapies
• UO
  University of California, Los Angeles