Phyre2.2: A Community Resource for Template-based Protein Structure Prediction
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Abstract
• Template-based structure prediction yields accurate models when there is a good query/template sequence similarity. • Phyre2.2 is the next generation of our template-based protein structure modelling portal Phyre2. • Phyre2.2 can identify a template from the AlphaFold database and model a protein not previously predicted by AlphaFold. • Phyre2.2 includes a template library that facilitates modelling of apo and holo structures. • Phyre2.2 employs a new ranking of hits that highlights models for different domains in the query. Template-based modelling, also known as homology modelling, is a powerful approach to predict the structure of a protein from its amino acid sequence. The approach requires one to…
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Topics
Keywords
- Protein structure prediction
- Computational biology
- Template
- Resource (disambiguation)
- Computer science
- Protein structure
- Artificial intelligence
- Chemistry
UN Sustainable Development Goals
- Zero hunger
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