Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children
Children's Hospital of Fudan University · Shanghai Jiao Tong University · +1 more institution
Abstract
Abstract The growth plate is crucial for skeletal growth in children, but research on repairing growth plate damage and restoring growth is limited. Here, a high-toughness adaptive dual-crosslinked hydrogel is designed to mimic the growth plate’s structure, supporting regeneration and bone growth. Composed of aldehyde-modified bacterial cellulose (DBNC), methacrylated gelatin (GelMA) and sodium alginate (Alg), the hydrogel is engineered through ionic bonding and Schiff base reactions, creating a macroporous structure. This structure can transform into a denser form by binding with calcium ions. In vitro, the loose macroporous structure of the hydrogels can promote chondrogenic differentiation, and when it…
Citation impact
- FWCI
- 18.99
- Percentile
- 100%
- References
- 58
Authors
7Topics & keywords
- Self-healing hydrogels
- Toughness
- Chemistry
- Biomedical engineering
- Materials science
- Nanotechnology
- Composite material
- Engineering