Roles of human papillomavirus in cancers: oncogenic mechanisms and clinical use

Human papillomaviruses, particularly high-risk human papillomaviruses, have been universally considered to be associated with the oncogenesis and progression of various cancers. The genome of human papillomaviruses is circular, double-stranded DNA that encodes early and late proteins. Each of the proteins is of crucial significance in infecting the epithelium of host cells persistently and supporting viral genome integrating into host cells. Notably, E6 and E7 proteins, classified as oncoproteins, trigger the incidence of cancers by fostering cell proliferation, hindering apoptosis, evading immune surveillance, promoting cell invasion, and disrupting the balance of cellular metabolism. Therefore, targeting…

• NN
  National Natural Science Foundation of China

  Award: 82272777
• DO
  Department of Science and Technology of Sichuan Province

  Awards: 2024NSFSC1510, 2024YFHZ0335
• SU
  Sichuan University

  Award: 2024HXBH111
• WC
  West China Hospital, Sichuan University

  Award: 2024HXBH111