Free radicals and their impact on health and antioxidant defenses: a review
Korea Research Institute of Bioscience and Biotechnology · Korea University of Science and Technology · +3 more institutions
Abstract
Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, as well as exogenous sources, including radiation, pollution, and smoking. While free radicals are essential for certain physiological processes, such as cell signaling and immune defense, their overproduction can disrupt the delicate balance between oxidants and antioxidants, leading to oxidative stress. Oxidative stress results in the damage of critical biomolecules like DNA, proteins, and lipids, contributing to the pathogenesis of…
Citation impact
- FWCI
- 338.40
- Percentile
- 100%
- References
- 225
Authors
8- NCNisansala ChandimaliCorresponding
Korea Research Institute of Bioscience and Biotechnology, Korea University of Science and Technology
- SGSeon Gyeong Bak
Korea Research Institute of Bioscience and Biotechnology
- EHEun Hyun Park
Chonnam National University, Korea Research Institute of Bioscience and Biotechnology
- HJHyung Jin Lim
Scripps Korea Antibody Institute
- YWYeong‐Seon Won
Topics & keywords
- Radical
- Oxidative stress
- Antioxidant
- Free-radical theory of aging
- Immune system
- DNA damage
- Cell biology
- Reactive oxygen species
- Good health and well-being