A Second Near-Infrared Window-Responsive Metal–Organic-Framework-Based Photosensitizer for Tumor Immunotherapy via Synergistic Ferroptosis and STING Activation

Zhao, Huan; Jin, Shujuan; Liu, Yang; Wang, Qian; Tan, Brynne Shu Ni; Wang, Shihuai; Han, Wang‐Kang; Niu, Xuping; Zhao, Yanli

doi:10.1021/jacs.4c13241

articleJournal of the American Chemical SocietyJan 24, 2025Closed access

A Second Near-Infrared Window-Responsive Metal–Organic-Framework-Based Photosensitizer for Tumor Immunotherapy via Synergistic Ferroptosis and STING Activation

HZHuan Zhao SJShujuan Jin YLYang Liu QWQian Wang BSBrynne Shu Ni Tan

Nanyang Technological University · Chinese PLA General Hospital · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced therapy precision and safety. To enhance deep tissue penetration and minimize tissue adsorption and phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significant potential. However, the efficacy of PDT is often impeded by tumor microenvironment hypoxia, primarily caused by irregular tumor vasculature. Fortunately, the stimulator of interferon genes (STING) pathway, known for immune activation, has been linked to vasculature normalization. In this study, we developed a nanoplatform (Fe-THBQ/SR) by loading a STING agonist (SR-717) into an…

Citation impact

53

total citations

FWCI: 27.72
Percentile: 100%
References: 61

Citations per year

Authors

9

Topics & keywords

Topics

Keywords

Chemistry
Photosensitizer
Sting
Therapeutic window
Infrared
Window (computing)
Immunotherapy
Metal

No related works found for this paper.