Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects in neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, and anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Dementia, Multiple Sclerosis (MS), Stroke, and Huntington's Disease (HD). Polyphenols have been extensively studied for their ability to regulate inflammatory responses by modulating the activity of pro-inflammatory genes and influencing signal…

• NR
  National Research Foundation

  Awards: 2020R1I1A2066868, 2020R1A5A2019413
• KH
  Korea Health Industry Development Institute

  Award: NRF-2020R1I1A2066868
• NR
  National Research Foundation of Korea

  Awards: 2020R1I1A2066868, NRF-2020R1I1A2066868, RS-2023-00279315, RS-2024-00350362, 2020R1A5A2019413
• MO
  Ministry of SMEs and Startups

  Award: RS-2024-00507224
• MO
  Ministry of Science and ICT, South Korea

  Award: 2020R1A5A2019413