Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets

Glutamine is the most abundant amino acid in human serum, and it can provide carbon and nitrogen for biosynthesis, which is crucial for proliferating cells. Moreover, it is widely known that glutamine metabolism is reprogrammed in cancer cells. Many cancer cells undergo metabolic reprogramming targeting glutamine, increasing its uptake to meet their rapid proliferation demands. An increasing amount of study is being done on the particular glutamine metabolic pathways in cancer cells.Further investigation into the function of glutamine in immune cells is warranted given the critical role these cells play in the fight against cancer. Immune cells use glutamine for a variety of biological purposes, including the…

• NN
  National Natural Science Foundation of China

  Awards: 82473238, 82203377
• NS
  Natural Science Foundation of Zhejiang Province

  Awards: JBZX-202007, LQ22H160036