Ferroptosis triggers mitochondrial fragmentation via Drp1 activation
University of Cologne · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · +5 more institutions
Abstract
Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases. The large GTPase Dynamin-related protein 1 (Drp1) is intimately involved in mediating constitutive mitochondrial fission and has been implicated in mitochondrial cell death pathways. During ferroptosis, a recently identified type of regulated necrosis driven by excessive lipid peroxidation, mitochondrial fragmentation has been observed. Yet, how this is regulated and whether it is involved in ferroptotic cell death has remained unexplored. Here, we provide evidence that Drp1 is activated upon experimental induction of ferroptosis and promotes cell…
Citation impact
- FWCI
- 55.68
- Percentile
- 100%
- References
- 65
Authors
13- LPLohans PedreraCorresponding
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
- LPLaura Prieto Clemente
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne
- ADAlina Dahlhaus
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne
- SLSara Lotfipour Nasudivar
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
- STSofya Tishina
University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne
Topics & keywords
- Cell biology
- Programmed cell death
- Mitochondrion
- Mitochondrial fission
- Fragmentation (computing)
- Biology
- MFN2
- Apoptosis
- Good health and well-being