Arginine metabolism in myeloid cells in health and disease

Metabolic flexibility is key for the function of myeloid cells. Arginine metabolism is integral to the regulation of myeloid cell responses. Nitric oxide (NO) production from arginine is vital for the antimicrobial and pro-inflammatory responses. Conversely, the arginase 1 (ARG1)-dependent switch between the branch of NO production and polyamine synthesis downregulates inflammation and promotes recovery of tissue homeostasis. Creatine metabolism is key for energy supply and proline metabolism is required for collagen synthesis. Myeloid ARG1 also regulates extracellular arginine availability and T cell responses in parasitic diseases and cancer. Cancer, surgery, sepsis and persistent inflammation in chronic…

• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFB-TRR 205 project A07, AL 1686/6-1, SFB-TRR 127 project A03
• TU
  Technische Universität Dresden
• DK
  Deutsche Krebshilfe
• SS
  Sächsisches Staatsministerium für Wissenschaft und Kunst