Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice
Peking University · Peking University First Hospital · +5 more institutions
Abstract
Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the reproductive toxicity of PLA in male mice and its potential mechanisms. To this end, our in vivo and in vitro experiments demonstrated that after degradation in the digestive system, a significant number of PLA-MP-derived nanoparticles could penetrate the blood-testis barrier (BTB) and localize within the spermatogenic microenvironment. Mice exposed to PLA-MPs for a long time exhibited significant reproductive toxicity, evidenced by decreased sperm concentration and…
Citation impact
- FWCI
- 29.39
- Percentile
- 100%
- References
- 62
Authors
12- QZQiancheng Zhao
Peking University, Peking University First Hospital
- ZFZishui Fang
Peking University, Peking University First Hospital
- PWPengcheng Wang
Peking University, Peking University Third Hospital
- ZQZhenwei Qian
King University, Peking University
- YYYuzhuo Yang
Peking University, Peking University First Hospital
Topics & keywords
- Spermatogenesis
- Reproductive toxicity
- Polylactic acid
- Toxicity
- Mitochondrion
- Mitochondrial toxicity
- Biology
- Cell biology