Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +6 more institutions
Abstract
, thereby inducing oxidative stress and promoting cancer cell death. However, within the complex tumor microenvironment (TME), the rational design of nanozymes and factors like activity, reaction substrates, and the TME itself significantly influence the efficiency of ROS generation. To address these limitations, recent research has focused on exploring the factors that affect activity and developing nanozyme-based cascade catalytic systems, which can trigger two or more cascade catalytic processes within tumors, thereby producing more therapeutic substances and achieving efficient and stable cancer therapy with minimal side effects. This area has shown remarkable progress. This Perspective provides a…
Citation impact
- FWCI
- 38.77
- Percentile
- 100%
- References
- 358
Authors
3- XJXiuna Jia
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, State Key Laboratory of Electroanalytical Chemistry
- EWErkang Wang
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, State Key Laboratory of Electroanalytical Chemistry
- JWJin WangCorresponding
State University of New York, Center for Theoretical Physics, Instituto de Física Teórica, University of Chinese Academy of Sciences, Stony Brook University
Topics & keywords
- Chemistry
- Rational design
- Cancer therapy
- Cascade
- Nanotechnology
- Biochemical engineering
- Cancer
- Combinatorial chemistry
- Good health and well-being