Asymmetric Functionalization Harnessing Radical‐Mediated Functional‐Group Migration
Shanghai Jiao Tong University · Shanghai Innovative Research Center of Traditional Chinese Medicine
Abstract
Along with the renaissance of radical chemistry, the past decade has witnessed rapid development in radical-mediated rearrangement reactions. A wide diversity of radical approaches harnessing functional-group migration (FGM) have been devised to enhance both synthetic efficiency and molecular complexity. However, the application of FGM reactions to construct stereogenic centers remains underexplored owing to the inherent challenges of asymmetric radical reactions. In this Minireview, we summarize the emerging area of asymmetric functionalization involving radical-mediated FGM reactions. Enantioselectivity can be regulated by chiral substrates, auxiliaries or reagents, or achieved through asymmetric…
Citation impact
- FWCI
- 31.38
- Percentile
- 100%
- References
- 67
Authors
3- FCFushan Chen
Shanghai Jiao Tong University, Shanghai Innovative Research Center of Traditional Chinese Medicine
- ZCZhu Cao
Shanghai Jiao Tong University, Shanghai Innovative Research Center of Traditional Chinese Medicine
- CZChen ZhuCorresponding
Shanghai Jiao Tong University, Shanghai Innovative Research Center of Traditional Chinese Medicine
Topics & keywords
- Stereocenter
- Functional diversity
- Functional group
- Surface modification
- The Renaissance
- Chemistry
- Combinatorial chemistry
- Enantioselective synthesis
- Reduced inequalities