Skeletal Editing through Cycloaddition and Subsequent Cycloreversion Reactions

ConspectusSkeletal editing, which involves adding, deleting, or substituting single or multiple atoms within ring systems, has emerged as a transformative approach in modern synthetic chemistry. This innovative strategy addresses the ever-present demand for developing new drugs and advanced materials by enabling precise modifications of molecular frameworks without disrupting essential functional complexities. Ideally performed at late stages of synthesis, skeletal editing minimizes the need for the cost- and labor-intensive processes often associated with de novo synthesis, thus accelerating the discovery and optimization of complex molecular architectures. While current efforts in skeletal editing…

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  Deutsche Forschungsgemeinschaft

  Award: STU 280/31-1