Heterogeneity in Cancer
Brown University · Morehouse School of Medicine · +1 more institution
Abstract
Cancer heterogeneity is a major challenge in oncology, complicating diagnosis, prognostication, and treatment. The clinical heterogeneity of cancer, which leads to differential treatment outcomes between patients with histopathologically similar cancers, is attributable to molecular diversity manifesting through genetic, epigenetic, transcriptomic, microenvironmental, and host biology differences. Heterogeneity is observed between patients, individual metastases, and within individual lesions. This review discusses clinical implications of heterogeneity, emphasizing need for personalized approaches to overcome challenges posed by cancer's diverse presentations. Understanding of emerging molecular diagnostic…
Citation impact
- FWCI
- 37.83
- Percentile
- 100%
- References
- 167
Authors
6Topics & keywords
- Tumour heterogeneity
- Genetic heterogeneity
- Tumor heterogeneity
- Cancer
- Liquid biopsy
- Epigenetics
- Metastasis
- Computational biology
- Good health and well-being