reviewAmerican Journal of HematologyJan 28, 2025HYBRID OA

Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy

MHMichael Hallek

University of Cologne · National Center for Tumor Diseases · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

DISEASE OVERVIEW: Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia. It typically occurs in older patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and apoptosis in clonal B-cells. DIAGNOSIS: The diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B-lymphocytes, which identify a clonal B-cell population carrying the CD5 antigen as well as typical B-cell markers. PROGNOSIS AND STAGING: Two clinical staging systems, Rai and Binet, provide prognostic information by using the results of physical examination and blood counts.…

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Topics & keywords

Topics
Keywords
  • Venetoclax
  • Medicine
  • Chronic lymphocytic leukemia
  • Ibrutinib
  • Oncology
  • CD5
  • Population
  • Internal medicine
UN Sustainable Development Goals
  • Good health and well-being
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