AlphaFold Protein Structure Database and 3D-Beacons: New Data and Capabilities

• AlphaMissense scores now integrated, enabling large-scale pathogenicity analysis of protein missense variants. • Foldseek added for rapid, accurate protein structure searches and comparisons. • Bulk data downloads introduced for enhanced analysis and workflow integration. • 3D-Beacons updates include AlphaMissense annotations and LevyLab’s homomeric models. • Training modules in "AlphaFold: A Practical Guide" enhance PDBe resources. The AlphaFold Protein Structure Database ( https://alphafold.ebi.ac.uk/ ) has made significant strides in enhancing its utility and accessibility for the life science research community. The recent integration of AlphaMissense predictions enables access to the pathogenicity of…

• NR
  National Research Foundation of Korea
• BA
  Biotechnology and Biological Sciences Research Council