Triggered “On/off” Luminescent Polypeptide Bowl‐Shaped Nanoparticles for Selective Lighting of Tumor Cells

Abstract Functional polymeric nanoparticles, especially those with anisotropic structures, have shown significant potential and advantages in biomedical applications including detecting, bioimaging, antimicrobial and anticancer. Herein, tetraphenylethylene (TPE) and azobenzene modified polypeptides of poly(( L ‐glutamic acid) tetraphenylethylene‐ stat ‐( L ‐glutamic acid)) (P(GATPE 9 ‐ stat ‐GA 25 )) and poly(( L ‐glutamic acid) azobenzene‐ stat ‐( L ‐glutamic acid)) (P(GAAzo 5 ‐ stat ‐GA 29 ) are synthesized, which self‐assemble into bowl‐shaped nanoparticles (BNPs) with controlled diameter, opening size and fluorescent property individually, or by co‐assembly. Due to the quenching effect of azobenzene, the…

• NN
  National Natural Science Foundation of China

  Awards: U22A20119, 22305102, 22301152
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20221097
• NS
  Natural Science Foundation of Ningxia Province

  Award: 2024AAC05030
• KR
  Key Research and Development Program of Ningxia

  Award: 2023BSB03062
• FR
  Fundamental Research Funds for the Central Universities

  Award: JUSRP123042