When short-chain fatty acids meet type 2 diabetes mellitus: Revealing mechanisms, envisioning therapies

Xie, Cong; Qi, Cong; Zhang, Jianwen; Wang, Wei; Meng, Xing; Aikepaer, Aifeila; Lin, Yuhan; Su, Chang; Liu, Yunlu; Feng, Xingzhong; Gao, Huijuan

doi:10.1016/j.bcp.2025.116791

reviewBiochemical PharmacologyJan 31, 2025HYBRID OA

When short-chain fatty acids meet type 2 diabetes mellitus: Revealing mechanisms, envisioning therapies

CXCong Xie CQCong Qi JZJianwen Zhang WWWei Wang XMXing Meng

Tsinghua University · Tianjin University of Traditional Chinese Medicine · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Evidence is accumulating that short-chain fatty acids (SCFAs) produced by the gut microbiota play pivotal roles in host metabolism. They contribute to the metabolic regulation and energy homeostasis of the host not only by preserving intestinal health and serving as energy substrates but also by entering the systemic circulation as signaling molecules, affecting the gut-brain axis and neuroendocrine-immune network. This review critically summarizes the current knowledge regarding the effects of SCFAs in the fine-tuning of the pathogenesis of type 2 diabetes mellitus (T2DM) and insulin resistance, with an emphasis on the complex relationships among diet, microbiota-derived metabolites, T2DM inflammation,…

Citation impact

43

total citations

FWCI: 27.99
Percentile: 100%
References: 214

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Authors

11

Topics & keywords

Topics

Keywords

Gut flora
Insulin resistance
Biology
Type 2 Diabetes Mellitus
Type 2 diabetes
Immune system
Energy homeostasis
Glucose homeostasis

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