Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues
Broad Institute · University of California, Los Angeles · +8 more institutions
Abstract
Non-communicable diseases (NCDs) such as cardiovascular diseases, chronic respiratory diseases, cancers, diabetes, and mental health disorders pose a significant global health challenge, accounting for the majority of fatalities and disability-adjusted life years worldwide. These diseases arise from the complex interactions between genetic, behavioral, and environmental factors, necessitating a thorough understanding of these dynamics to identify effective diagnostic strategies and interventions. Although recent advances in multi-omics technologies have greatly enhanced our ability to explore these interactions, several challenges remain. These challenges include the inherent complexity and heterogeneity of…
Citation impact
- FWCI
- 82.17
- Percentile
- 100%
- References
- 247
Authors
7- RARobel AlemuCorresponding
Broad Institute, University of California, Los Angeles, The University of Adelaide, Anderson University - South Carolina
- NTNigussie Tadesse Sharew
The University of Adelaide
- YYYodit Y. Arsano
Brown University, Lifespan
- MBMuktar Beshir Ahmed
The University of Adelaide
- FTFasil Tekola‐Ayele
National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Topics & keywords
- Human genetics
- Computational biology
- Equity (law)
- Omics
- Biology
- Translation (biology)
- Systems biology
- Gene
- Partnerships for the goals