articleAdvanced ScienceJan 31, 2025GOLD OA

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer

ZYZhou YangWSWei SuQZQinglin ZhangLNLili NiuBFBaijie Feng

Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +8 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through drug screening, it is found that histone deacetylase inhibitor (HDACi) significantly sensitized CRC to ferroptosis. The combination of HDACi and ferroptosis inducers synergically suppresses CRC growth both in vivo and in vitro. Mechanically, HDACi reduces ferroptosis suppressor protein (FSP1) by promoting its mRNA degradation. Specifically, it is confirmed that HDACi specifically targets HDAC1 and promotes the H3K27ac modification of fat mass‐ and obesity‐associated gene (FTO) and AlkB Homolog 5, RNA Demethylase (ALKBH5), which results in significant activation of FTO and…

Citation impact

66
total citations
FWCI
41.28
Percentile
100%
References
46
Citations per year

Authors

18

Topics & keywords

Topics
Keywords
  • Demethylase
  • Trichostatin A
  • Cancer research
  • HDAC1
  • Gene silencing
  • Histone deacetylase
  • Vorinostat
  • Chemistry
UN Sustainable Development Goals
  • Good health and well-being
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