Mitochondrial Dysfunction in Neurodegenerative Diseases: Mechanisms and Corresponding Therapeutic Strategies

Neurodegenerative disease (ND) refers to the progressive loss and morphological abnormalities of neurons in the central nervous system (CNS) or peripheral nervous system (PNS). Examples of neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Recent studies have shown that mitochondria play a broad role in cell signaling, immune response, and metabolic regulation. For example, mitochondrial dysfunction is closely associated with the onset and progression of a variety of diseases, including ND, cardiovascular diseases, diabetes, and cancer. The dysfunction of energy metabolism, imbalance of mitochondrial dynamics, or abnormal mitophagy…

• NN
  National Natural Science Foundation of China

  Award: 81700055
• GO
  Government of Jiangsu Province
• NS
  Natural Science Foundation of Jiangsu Province

  Awards: D2016021, G2Y-kJS-SD-2023-097, 600791001, 81700055, tsqn201909147, JYHL2021MS13, BK20160229
• SA
  State Administration of Traditional Chinese Medicine of the People's Republic of China
• JM
  Jining Medical University

  Award: 600791001
• XM
  Xuzhou Medical University

  Awards: D2016021, BK20160229