Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
University of Basel · University of Zurich · +13 more institutions
Abstract
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per day) and/or omega-3 (1 g per day) and/or a home exercise program on four next-generation DNA methylation (DNAm) measures of biological aging (PhenoAge, GrimAge, GrimAge2 and DunedinPACE) over 3 years. Omega-3 alone slowed the DNAm clocks PhenoAge, GrimAge2 and DunedinPACE, and all three treatments had additive benefits on PhenoAge. Overall, from baseline to year…
Citation impact
- FWCI
- 56.29
- Percentile
- 100%
- References
- 75
Authors
17- HAHeike A. Bischoff‐FerrariCorresponding
University of Basel, University of Zurich, Felix Platter-Hospital
- SGStephanie Gängler
University of Basel, University of Zurich, Felix Platter-Hospital
- MWMaud Wieczorek
University of Basel, University of Zurich, Felix Platter-Hospital
- DWDaniel W. Belsky
Columbia University
- JRJoanne Ryan
Monash University
Topics & keywords
- Vitamin D and neurology
- Observational study
- Clinical trial
- Medicine
- Randomized controlled trial
- DNA methylation
- dNaM
- Internal medicine