reviewMoleculesFeb 1, 2025GOLD OA

Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties

BEBasma Es-SaiHWHicham WahnouSBS. BenayadSRSoufiane RabbaaYLYassir Laaziouez

Université Hassan 1er · University of Hassan II Casablanca · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Gamma-tocopherol (γ-tocopherol), a major isoform of vitamin E, exhibits potent antioxidant, anti-inflammatory, and anticancer properties, making it a promising therapeutic candidate for treating oxidative stress-related diseases. Unlike other tocopherol isoforms, γ-tocopherol effectively neutralizes reactive oxygen species (ROS) and reactive nitrogen species (RNS), providing robust cellular protection against oxidative damage and lipid peroxidation. Its anti-inflammatory effects are mediated through the modulation of pathways involving cyclooxygenase-2 (COX-2) and tumor necrosis factor-alpha (TNF-α), reducing chronic inflammation and its associated risks. In cancer therapy, γ-tocopherol demonstrates…

Citation impact

62
total citations
FWCI
36.86
Percentile
100%
References
92
Citations per year

Authors

8

Topics & keywords

Topics
Keywords
  • Oxidative stress
  • Inflammation
  • Pharmacology
  • Reactive oxygen species
  • Vitamin E
  • Antioxidant
  • Medicine
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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