Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites

Teng, Yun; Luo, Chao; Qiu, Xiaolan; Mu, Jingyao; Sriwastva, Mukesh K.; Xu, Qingbo; Liu, Minmin; Hu, Xin; Xu, Fangyi; Zhang, Lifeng; Park, Juw Won; Hwang, Jae Yeon; Kong, Maiying; Liu, Zhanxu; Zhang, Xiang; Xu, Raobo; Yan, Jun; Merchant, Michael L.; McClain, Craig J.; Zhang, Huang‐Ge

doi:10.1038/s41467-025-56498-2

articleNature CommunicationsFeb 3, 2025GOLD OA

Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites

YTYun Teng CLChao Luo XQXiaolan Qiu JMJingyao Mu MKMukesh K. Sriwastva

University of Louisville · Xuzhou Medical College · +5 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate the impact of plant-derived nanoparticles (PNP) on gut microbiota and metabolites in context of cancer immunotherapy with the humanized gnotobiotic mouse model. Specifically, we show that ginger-derived exosome-like nanoparticle (GELN) preferentially taken up by Lachnospiraceae and Lactobacillaceae mediated by digalactosyldiacylglycerol (DGDG) and glycine, respectively. We further demonstrate that GELN aly-miR159a-3p enhances anti-PD-L1 therapy in melanoma by inhibiting the expression of recipient bacterial phospholipase C (PLC)…

Citation impact

59

total citations

FWCI: 36.36
Percentile: 100%
References: 117

Citations per year

Authors

20

Topics & keywords

Topics

Keywords

Gut flora
Biology
Lachnospiraceae
Immunotherapy
Cancer immunotherapy
Context (archaeology)
Immune system
Biochemistry

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.