Epidemiology and Genetic Traits of Carbapenemase-Producing Enterobacterales: A Global Threat to Human Health
University of Padua · Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · +6 more institutions
Abstract
Carbapenemase-producing Enterobacterales (CPE) represent an important threat to global health, resulting in an urgent issue in clinical settings. CPE often exhibit a multidrug-resistant (MDR) phenotype, thus reducing the antimicrobial armamentarium, with few antibiotics retaining residual antimicrobial activity against these pathogens. Carbapenemases are divided into three classes (A, B, and D) according to the Ambler classification system. Among these, KPC (class A), NDM, VIM, IMP (class B), and OXA-48-like (class D) represent the most important carbapenemases in terms of diffusion and clinical impact. CPE diffusion has been observed worldwide, with current endemicity in multiple territories around the world.…
Citation impact
- FWCI
- 19.66
- Percentile
- 100%
- References
- 105
Authors
8- GAGualtiero Alvisi
University of Padua
- ACAntonio Curtoni
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin
- RFRossella Fonnesu
Azienda Ospedaliera Universitaria Integrata Verona
- APAurora Piazza
University of Pavia
- CSCaterina Signoretto
University of Verona, Azienda Ospedaliera Universitaria Integrata Verona
Topics & keywords
- Antibiotic resistance
- Context (archaeology)
- Biology
- Transmission (telecommunications)
- Antimicrobial
- Global health
- Plasmid
- Epidemiology
- Good health and well-being