NIR‐II Fluorescent Thermophoretic Nanomotors for Superficial Tumor Photothermal Therapy

Peritumoral subcutaneous injection has been highly envisioned as an efficient yet low-risk administration of photothermal agents for superficial tumor photothermal therapy. However, obstructed by complex subcutaneous tissue, the delivery of injected photothermal agents to the specific tumor remains a critical issue. Herein, the study reports a polydopamine (PDA)-encapsulated spherical core/shell nanomotor with fluorescent indocyanine green (ICG) immobilized on its PDA shell. Upon the first near-infrared (NIR-I) irradiation, this motor can generate favorable photothermal heat, and meantime, emit a robust ICG fluorescence in the second near-infrared window (NIR-II). The heat turns the motor into an active…

• NN
  National Natural Science Foundation of China

  Awards: 82001845, 22173068
• M
  Max-Planck-Gesellschaft
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions

  Award: 111 Project
• HE
  Higher Education Discipline Innovation Project
• SU
  Suzhou University

  Award: 2021XJPT06
• NS
  Natural Science Foundation of Anhui Province

  Award: 2108085MB67
• NK
  National Key Research and Development Program of China

  Award: 2018YFE0306105