Cuproptosis-Inducing Functional Nanocomposites for Enhanced and Synergistic Cancer Radiotherapy
Shanghai Jiao Tong University · Shanghai Chest Hospital · +7 more institutions
Abstract
Radiotherapy is crucial in local cancer management and needs advancements. Tumor cells elevate intracellular copper levels to promote growth and resist radiation; thus, targeted copper delivery to mitochondria could enhance radiotherapy by inducing cuproptosis in tumor cells. In this study, we engineered a multifunctional nanoliposome complex, termed Lipo-Ele@CuO2, which encapsulates both copper peroxide (CuO2) and the copper chelator elesclomol, which can delivery Cu ions to the mitochondria. The Lipo-Ele@CuO2 complex induces mitochondria-mediated cuproptosis in tumor cells and synergistically enhances the efficacy of radiotherapy. CuO2 acts as a copper donor and exhibits inherent sensitivity to acidic…
Citation impact
- FWCI
- 21.96
- Percentile
- 100%
- References
- 57
Authors
10- TJTiaoyan Jiang
Shanghai Jiao Tong University, Shanghai Chest Hospital
- TJTian-Ying Jia
Shanghai Jiao Tong University, Shanghai Chest Hospital
- YYYipengchen Yin
Shanghai Jiao Tong University, Shanghai Chest Hospital
- TLTianyu Li
Fudan University Shanghai Cancer Center
- XSXinran Song
Shanghai University
Topics & keywords
- Radiation therapy
- Cancer research
- Cancer cell
- Tumor microenvironment
- Mitochondrion
- Intracellular
- Radioresistance
- Chemistry