Activatable Photosensitizers: From Fundamental Principles to Advanced Designs
University Health Network · Princess Margaret Cancer Centre · +1 more institution
Abstract
Photodynamic therapy (PDT) is a promising treatment that uses light to excite photosensitizers in target tissue, producing reactive oxygen species and localized cell death. It is recognized as a minimally invasive, clinically approved cancer therapy with additional preclinical applications in arthritis, atherosclerosis, and infection control. A hallmark of ideal PDT is delivering disease-specific cytotoxicity while sparing healthy tissue. However, conventional photosensitizers often suffer from non-specific photoactivation, causing off-target toxicity. Activatable photosensitizers (aPS) have emerged as more precise alternatives, offering controlled activation. Unlike traditional photosensitizers, they remain…
Citation impact
- FWCI
- 39.29
- Percentile
- 100%
- References
- 265
Authors
4- NKNahyun Kwon
University Health Network, Princess Margaret Cancer Centre
- HWHanyi Weng
University of Toronto, Princess Margaret Cancer Centre
- MAManeesha A RojoraCorresponding
University of Toronto, Princess Margaret Cancer Centre
- GZGang ZhengCorresponding
University of Toronto, Princess Margaret Cancer Centre
Topics & keywords
- Photodynamic therapy
- Collateral damage
- Chemistry
- Quenching (fluorescence)
- Internalization
- Cancer research
- Nanotechnology
- Fluorescence