Engineered commensals for targeted nose-to-brain drug delivery

Shen, Haosheng; Aggarwal, Nikhil; Cui, Beiming; Foo, Guo Wei; He, Yuanzhi; Srivastava, S. K.; Li, Shengjie; Seah, Marcus Ze Xian; Wun, K.S.; Ling, Hua; Hwang, In Young; Ho, Chun Loong; Lee, Yung Seng; Chang, Matthew Wook

doi:10.1016/j.cell.2025.01.017

articleCellFeb 5, 2025HYBRID OA

Engineered commensals for targeted nose-to-brain drug delivery

HSHaosheng Shen NANikhil AggarwalBCBeiming CuiGWGuo Wei Foo YHYuanzhi He

National University of Singapore · Chinese Academy of Sciences · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Intranasal administration through the olfactory epithelium (OE) presents a direct pathway for brain-targeted therapeutic delivery, although its feasibility is hampered by the anatomical and absorptive limitations of the OE. In this study, we identified Lactobacillus plantarum WCFS1 (Lp), a commensal strain with a natural affinity for the OE and engineered it to function as a vector for cerebral drug delivery. Upon intranasal administration, Lp released specific payload molecules within the OE, with subsequent transport and accumulation in the brain. The therapeutic efficacy of Lp was further validated by the recombinant production and secretion of appetite-regulating hormones. When administered intranasally in…

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79

total citations

FWCI: 47.55
Percentile: 100%
References: 95

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Authors

14

HS
Haosheng ShenCorresponding
National University of Singapore
NA
Nikhil Aggarwal
National University of Singapore
BC
Beiming Cui
Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology
GW
Guo Wei Foo
National University of Singapore
YH
Yuanzhi He
National University of Singapore

Topics & keywords

Topics

Keywords

Biology
Commensalism
Drug
Targeted drug delivery
Computational biology
Pharmacology
Genetics
Bacteria

UN Sustainable Development Goals

Good health and well-being

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