A comprehensive spatio-cellular map of the human hypothalamus
University of Cambridge · Cambridge University Hospitals NHS Foundation Trust · +11 more institutions
Abstract
Abstract The hypothalamus is a brain region that plays a key role in coordinating fundamental biological functions 1 . However, our understanding of the underlying cellular components and neurocircuitries have, until recently, emerged primarily from rodent studies 2,3 . Here we combine single-nucleus sequencing of 433,369 human hypothalamic cells with spatial transcriptomics, generating a comprehensive spatio-cellular transcriptional map of the hypothalamus, the ‘HYPOMAP’. Although conservation of neuronal cell types between humans and mice, as based on transcriptomic identity, is generally high, there are notable exceptions. Specifically, there are significant disparities in the identity of…
Citation impact
- FWCI
- 46.94
- Percentile
- 100%
- References
- 81
Authors
17- JAJohn A. Tadross
University of Cambridge, Cambridge University Hospitals NHS Foundation Trust, Wellcome/MRC Institute of Metabolic Science, Medical Research Council
- LSLukas Steuernagel
Max Planck Institute for Metabolism Research
- GKGeorgina K.C. Dowsett
University of Cambridge, Wellcome/MRC Institute of Metabolic Science, Medical Research Council
- KAKatherine A. Kentistou
University of Cambridge, MRC Epidemiology Unit, Medical Research Council
- SLSofia Lundh
Novo Nordisk (Denmark)
Topics & keywords
- Biology
- Transcriptome
- Hypothalamus
- Context (archaeology)
- Population
- Gene
- RNA-Seq
- Neuroscience
- Life in Land