A Wireless Operated Flexible Bioelectronic Microneedle Patch for Actively Controlled Transdermal Drug Delivery

Precise control over drug release rates is critical for enhancing therapeutic efficacy, reducing side effects, and maintaining stable drug levels. While microneedles (MNs) offer a promising approach for transdermal drug delivery, conventional passive-response systems often lack adaptability across diverse drugs and disease models, limiting their versatility. Here, this work presents a flexible bioelectronic microneedle patch (FBMP) that integrates flexible electronics for actively controlled transdermal delivery. The FBMP incorporates a flexible printed circuit board (FPCB), a eutectic gallium-indium (EGaIn) heating film, and dual-layer microneedles with a polyvinyl alcohol (PVA) core and polycaprolactone…

• NN
  National Natural Science Foundation of China

  Award: 52373135
• GP
  Guangdong Provincial Pearl River Talents Program

  Award: 2019QN01Y088
• NK
  National Key Research and Development Program of China

  Award: 2022YFB3804700