reviewBiologyFeb 6, 2025GOLD OA

Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts

AAAhmad Almatroudi

Qassim University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Healthcare-associated infections pose a significant global health challenge, negatively impacting patient outcomes and burdening healthcare systems. A major contributing factor to healthcare-associated infections is the formation of biofilms, structured microbial communities encased in a self-produced extracellular polymeric substance matrix. Biofilms are critical in disease etiology and antibiotic resistance, complicating treatment and infection control efforts. Their inherent resistance mechanisms enable them to withstand antibiotic therapies, leading to recurrent infections and increased morbidity. This review explores the development of biofilms and their dual roles in health and disease. It highlights the…

Citation impact

102
total citations
FWCI
63.19
Percentile
100%
References
385
Citations per year

Authors

1

Topics & keywords

Topics
Keywords
  • Biofilm
  • Antibiotic resistance
  • Biology
  • Intensive care medicine
  • Infection control
  • Disease
  • Antibiotics
  • Antimicrobial
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