Nitric Oxide-Producing Multiple Functional Nanoparticle Remodeling Tumor Microenvironment for Synergistic Photodynamic Immunotherapy against Hypoxic Tumor
Peking University · Peking University Third Hospital · +2 more institutions
Abstract
The treatment of pancreatic cancer faces significant challenges due to connective tissue hyperplasia and severe hypoxia. Unlike oxygen-dependent Type II photosensitizers, Type I photosensitizers can produce a substantial amount of reactive oxygen species, even under hypoxic conditions, making them more suitable for photodynamic therapy of pancreatic cancer. However, the dense extracellular matrix of pancreatic cancer limits the penetration efficiency of photosensitizers, and the presence of immunosuppressive cells in the tumor microenvironment reduces the therapeutic effect. To address these challenges, we designed the photoimmunotherapeutic M1@PAP nanoparticles composed of Type I photosensitizer and…
Citation impact
- FWCI
- 22.49
- Percentile
- 100%
- References
- 46
Authors
8Topics & keywords
- Tumor microenvironment
- Nitric oxide
- Immunotherapy
- Cancer research
- Photodynamic therapy
- Nanoparticle
- Cancer immunotherapy
- Chemistry