Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Liver repair and regeneration are crucial physiological responses to hepatic injury and are orchestrated through intricate cellular and molecular networks. This review systematically delineates advancements in the field, emphasizing the essential roles played by diverse liver cell types. Their coordinated actions, supported by complex crosstalk within the liver microenvironment, are pivotal to enhancing regenerative outcomes. Recent molecular investigations have elucidated key signaling pathways involved in liver injury and regeneration. Viewed through the lens of metabolic reprogramming, these pathways highlight how shifts in glucose, lipid, and amino acid metabolism support the cellular functions essential…

• NN
  National Natural Science Foundation of China

  Awards: ZYJC18008, 82270643, 82070644, 82170621
• SU
  Sichuan University

  Award: ZYJC18008
• WC
  West China Hospital, Sichuan University

  Awards: ZYJC18008, ZYGD22006, 1.3.5