Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. Oxidative stress is caused mainly by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant system in cancer cells. Emerging evidence has reported that oxidative stress regulates the expression and activity of lipid metabolism-related enzymes, leading to the alteration of cellular lipid metabolism; this involves a significant increase in fatty acid synthesis and a shift in the way in which lipids are taken up and utilized. The dysregulation of lipid metabolism provides abundant intermediates to synthesize biological macromolecules for…

• NN
  National Natural Science Foundation of China

  Awards: 2024HXBH163, 2024YFFK0383, 2025ZNSFSC1805, 82072933, 2023ZYD0044, 82272892, 82404000
• DO
  Department of Science and Technology of Sichuan Province

  Awards: 2024YFFK0383, 2023ZYD0044, 82072933, 82272892, 82404000, 2024HXBH163, 2025ZNSFSC1805
• SU
  Sichuan University
• WC
  West China Hospital, Sichuan University