The role of HIF-1α in hypoxic metabolic reprogramming in osteoarthritis
Gansu University of Traditional Chinese Medicine
Abstract
The joint dysfunction caused by osteoarthritis (OA) is increasingly becoming a major challenge in global healthcare, and there is currently no effective strategy to prevent the progression of OA. Therefore, better elucidating the relevant mechanisms of OA occurrence and development will provide theoretical basis for formulating new prevention and control strategies. Due to long-term exposure of cartilage tissue to the hypoxic microenvironment of joints, metabolic reprogramming changes occur. Hypoxia-inducible factor-1alpha (HIF-1α), as a core gene regulating hypoxia response in vivo, plays an important regulatory role in the hypoxic metabolism of chondrocytes. HIF-1α adapts to the hypoxic microenvironment by…
Citation impact
- FWCI
- 31.32
- Percentile
- 100%
- References
- 182
Authors
10- JZJie ZhangCorresponding
Gansu University of Traditional Chinese Medicine
- PGPeng Gao
Gansu University of Traditional Chinese Medicine
- WCWeirong Chang
Gansu University of Traditional Chinese Medicine
- JSJiayi Song
Gansu University of Traditional Chinese Medicine
- FAFang-Yu An
Gansu University of Traditional Chinese Medicine
Topics & keywords
- Reprogramming
- Hypoxia (environmental)
- Osteoarthritis
- Chemistry
- Medicine
- Biochemistry
- Pathology
- Gene
- Zero hunger