Osteomimix: A Multidimensional Biomimetic Cascade Strategy for Bone Defect Repair

Despite advancements in biomimetic mineralization techniques, the repair of large-scale bone defects remains a significant challenge. Inspired by the bone formation process, a multidimensional biomimetic cascade strategy is developed by replicating the biomineralization cascade, emulating the hierarchical structure of bone, and biomimicking its biological functions for efficient bone regeneration. This strategy involves the photocrosslinking of sodium methacrylate carboxymethyl cellulose-stabilized amorphous magnesium-calcium phosphate with methacrylate-modified type I collagen to create a self-mineralizing hydrogel. The hydrogel is then integrated with either naturally derived or synthetic oriented bulk…

• NN
  National Natural Science Foundation of China

  Awards: 82371004, 82271010
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2042024YXB020